Cardiac arrest & resuscitation
Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest: A Retrospective Multicenter Cohort Study
Main finding · Favorable neurologic outcomeResult — go to the resultAdjusted odds ratio 5.12 95% CI 2.98–8.80Authors' conclusion
In this retrospective multicenter cohort study, although most patients with OHCA underwent ECPR for cardiac causes, accidental hypothermia was associated with favorable neurologic outcome and survival; in contrast, acute aortic dissection/aneurysm and primary cerebral disorders were associated with nonsurvival compared with cardiac causes.
Study context
- Population
- Adults with out-of-hospital cardiac arrest (OHCA) who underwent extracorporeal CPR (ECPR) at 36 institutions in Japan, 2013–2018
- Participants
- 1,781 adults · 36 institutions
- Exposure
- Etiologies of cardiac arrest vs cardiac causes
- Cardiac causesn = 1,405reference
- Outcome
- Favorable neurologic outcome and survival
- Follow-up
- Hospital discharge
Methodological detailsmulticentre registry
- Multicentre registry
Main finding
Favorable neurologic outcome
Adjusted odds ratio
5.12
95% CI 2.98–8.80
P < 0.001
Accidental hypothermia vs Cardiac causes
aOR 5.12 (95% CI 2.98–8.80); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR for survival (95% CI) | P value | |
|---|---|---|---|
| Survival at hospital discharge, by etiology (reference: cardiac causes)Accidental hypothermia vs Cardiac causes · significantly higher survival · multivariable logistic regression | 5.19 (3.15–8.56) | P < 0.001 | |
| Survival at hospital discharge, by etiology (reference: cardiac causes)Acute aortic dissection/aneurysm vs Cardiac causes · significantly lower survival · multivariable logistic regression | 0.07 (0.02–0.28) | P < 0.001 | |
| Survival at hospital discharge, by etiology (reference: cardiac causes)Primary cerebral disorders vs Cardiac causes · significantly lower survival · multivariable logistic regression | 0.12 (0.03–0.50) | P = 0.004 | |
| 0.050.21520AOR for survival (log scale) |
Original publication
Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest: A Retrospective Multicenter Cohort Study. Chest. Published 23 October 2023. doi:10.
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