Anesthetic drugs & techniques

European Malignant Hyperthermia Group 2025 guidelines for the investigation of malignant hyperthermia susceptibility

Br J AnaesthPublished Guideline

An erratum to this article was published (Br J Anaesth, Oct 2026 ↗)

Methodological detailsconsensus
  • Consensus

Recommendations

As issued by the authors

  1. New diagnostic designation, the malignant hyperthermia (MH) genotype, introduced in addition to classification of MH susceptibility by the in vitro halothane/caffeine contracture test

  2. Revised diagnostic pathways include the adapted European Malignant Hyperthermia Group curation system for classifying genetic variants by relevance to MH

  3. Minor changes to the in vitro halothane/caffeine contracture test protocol; updated patient referral criteria and clinical interpretation of diagnostic results

  4. First consensus definition of a clinical MH event

Original publication

European Malignant Hyperthermia Group 2025 guidelines for the investigation of malignant hyperthermia susceptibility. Br J Anaesth. Published 1 January 2026. doi:10.1016/j.bja.2025.11.006

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