Myopathic manifestations across the adult lifespan of patients with malignant hyperthermia susceptibility: a narrative review
Study context
- Population
- Adults with malignant hyperthermia susceptibility (MHS)
- Outcome
- MHS-related myopathy: clinical presentation, biochemical and histopathological findings, impact on well-being
Methodological detailsexpert opinion, European Malignant Hyperthermia Group request
- Expert opinion
- European Malignant Hyperthermia Group request
Main finding
As reported in the abstract
- Symptoms: muscle cramps, stiffness, myalgias, rhabdomyolysis, weakness; wide age range of onset, mainly in adulthood
- Histopathology may show nonspecific abnormalities suggestive of RYR1 involvement
- Metabolic profiling reflects altered energy metabolism in MHS muscle
- Myopathic manifestations can significantly impact quality of life, with functional limitations and socio-economic burden
- Available therapies can provide symptomatic relief
Original publication
Myopathic manifestations across the adult lifespan of patients with malignant hyperthermia susceptibility: a narrative review. Br J Anaesth. Published 5 August 2024. doi:10.
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