Neuroanesthesia & neurocritical care
Evaluating extreme temperature values and patient outcomes in aneurysmal subarachnoid hemorrhage: Post-hoc insights from the Earlydrain trial
Authors' conclusion
Extreme temperature values significantly influence outcomes in aSAH.
Study context
- Population
- Patients with aneurysmal SAH in neurocritical care (Earlydrain trial)
- Participants
- 287 patients
- Comparison
- Body temperature thresholds (>38.0 °C, >38.2 °C, >39.0 °C, <36.0 °C) during the first 8 days of neurocritical care
- Primary endpoint
- Unfavorable outcome, modified Rankin Scale (mRS) >2
- Follow-up
- 180 days
Methodological detailspost-hoc analysis, Generalized Estimating Equations, adjusted for hemorrhage severity, age, intracerebral and intraventricular hemorrhage, infection and lumbar drainage
- Post-hoc analysis
- Generalized Estimating Equations
- Adjusted for hemorrhage severity, age, intracerebral and intraventricular hemorrhage, infection and lumbar drainage
Primary result
As reported in the abstract
Unfavorable mRS >2 at 180 days
Adjusted odds ratio
2.60
P = 0.002
Temperature >39 °C
Adjusted odds ratio
3.82
P = 0.02
Temperature <36 °C
Further findings
Secondary infarctions
- Not significantly related to temperature extremes
Original publication
Evaluating extreme temperature values and patient outcomes in aneurysmal subarachnoid hemorrhage: Post-hoc insights from the Earlydrain trial. J Crit Care. Published 7 May 2025. doi:10.
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