ICU sedation, delirium & recovery
Evaluation of Etomidate Use and Association with Mortality Compared with Ketamine among Critically Ill Patients
Authors' conclusion
Use of etomidate on the day of IMV initiation is common and associated with a higher odds of hospital mortality than use of ketamine.
Study context
- Population
- ICU patients receiving invasive mechanical ventilation, Premier Healthcare Database, 2008–2021
- Participants
- 1,689,945 patients · 22,273 matched pairs
- Exposure
- Etomidate vs ketamine on the day of invasive mechanical ventilation (IMV) initiation
- Outcome
- Hospital mortality
Methodological detailspropensity-score matched, multivariable regression
- Propensity-score matched
- Multivariable regression
Main finding
As reported in the abstract
Each group vs ketamineAbsolute risk difference (95% CI)
Etomidate
2.8%(2.1%–3.6%)
Each group vs ketamineAdjusted odds ratio (95% CI)
Etomidate
1.28(1.21,1.34)
Observational data: associations, not effects.
Further findings
- Etomidate use among all IMV patients
- 43.7% · 738,855 events
Subgroups and sensitivity analyses (subgroup)
- Association consistent across subgroups and sensitivity analyses
Effect modification by corticosteroids after intubation
- No attenuation of the association with mortality with receipt of corticosteroids after etomidate use
Original publication
Evaluation of Etomidate Use and Association with Mortality Compared with Ketamine among Critically Ill Patients. Am J Respir Crit Care Med. Published 15 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →