Perioperative medicine & outcomes

Evidence on Enhanced Recovery After Surgery Protocols in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis of Postoperative Outcomes

Anesth AnalgPublished Systematic review and meta-analysis of clinical trials and observational studies

Pooled result · Postoperative morbidityResult — go to the resultRelative risk 0.63 95% CI 0.66–0.55

Authors' conclusion

ERAS protocols represent a practical approach to improving surgical outcomes in LMICs, with evidence showing reduced postoperative morbidity and hospital stay, without an increase in readmission or mortality.

Study context

Population
Surgical patients in low- and middle-income countries (LMICs), mostly abdominal surgery35 studies (23 trials, 12 observational)
Participants
3,163 vs 3,243
Comparison
Enhanced Recovery After Surgery (ERAS) protocols vs routine perioperative care
  • ERASn = 3,163
  • Routine caren = 3,243reference
Outcome
Postoperative morbidity
Methodological details84% of publications from South and Southeast Asia, Risk of bias: Cochrane risk of bias tool and Newcastle-Ottawa scale
  • 84% of publications from South and Southeast Asia
  • Risk of bias: Cochrane risk of bias tool and Newcastle-Ottawa scale

Pooled result

As reported in the abstract

Relative risk

0.63

95% CI 0.66–0.55

Further pooled results

OutcomeSMD (95% CI)
Postoperative hospital LOSI 2 = 86.7−0.68 (−0.47 to −0.90)

30-day postoperative mortality and readmission

No significant difference

Original publication

Evidence on Enhanced Recovery After Surgery Protocols in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis of Postoperative Outcomes. Anesth Analg. Published 29 January 2026. doi:10.1213/ane.0000000000007875

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