Evolution of organ dysfunction in transferred vs non-transferred patients with community sepsis: A propensity-matched analysis
Main finding · ΔSOFA at 72 hResult — go to the resultMean difference - 1.25 95% CI −2.37 to −0.13Authors' conclusion
In this propensity-matched analysis, interhospital transfer was associated with greater early improvement in organ dysfunction among patients with community-onset sepsis.
Study context
- Population
- Adults (≥18 years) with community-onset sepsis, January 2017 to December 202060 (0.95%) transferred
- Participants
- 6,264 adults
- Exposure
- Interhospital transfer to a referral center vs local admission
- Transferredn = 56
- Non-transferredn = 56reference
- Outcome
- Change in Sequential Organ Failure Assessment (SOFA) score from ED presentation to 72 h (ΔSOFA)
- Follow-up
- 72 h
Methodological detailspropensity-score matched (1:1)
- Propensity-score matched (1:1)
Main finding
ΔSOFA at 72 h
Mean difference
- 1.25
95% CI −2.37 to −0.13
P = 0.03
Transferred vs Non-transferred
mean difference - 1.25 (95% CI −2.37 to −0.13); P = 0.03
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Difference (95% CI) | P value | |
|---|---|---|---|
| ΔSOFA max at 48 hMatched cohort | −1.14 (−2.23 to −0.06) | P = 0.04 | |
| −3−2−101Difference (linear scale) |
ICU admission before matching · prior to matching
P < 0.001
ΔSOFA at 96 h
- No significant differences at 96 h
Original publication
Evolution of organ dysfunction in transferred vs non-transferred patients with community sepsis: A propensity-matched analysis. J Crit Care. Published 10 June 2026. doi:10.
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