Respiratory failure & ventilation
Expiratory Muscle Activity Counteracts Positive End-Expiratory Pressure and Is Associated with Fentanyl Dose in Patients with Acute Respiratory Distress Syndrome
Authors' conclusion
Administration of NMBAs during EIT monitoring revealed activity of expiratory muscles in half of patients with ARDS. The resultant increase in EELI had a dose-response relationship with fentanyl dosage.
Study context
- Population
- Mechanically ventilated patients with acute respiratory distress syndrome (ARDS) monitored with electrical impedance tomography who received neuromuscular blocking agents (NMBAs)plus 10 with esophageal catheters
- Participants
- 46 participants
- Exposure
- End-expiratory lung impedance before vs after NMBA administration
- Outcome
- EELI increase >10% of corresponding Vt after NMBA
Methodological detailstwo-centre, electrical impedance tomography monitoring
- Two-centre
- Electrical impedance tomography monitoring
Main finding
As reported in the abstract
Half of patients showed an increase in end-expiratory lung impedance (EELI) of >10% of the corresponding Vt
46.2%; IQR, 23.9-60.9%
Observational data: associations, not effects.
Further findings
Factors associated with degree of EELI increase
- Correlated positively with fentanyl dosage and negatively with changes in end-expiratory pleural pressures
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Expiratory Muscle Activity Counteracts Positive End-Expiratory Pressure and Is Associated with Fentanyl Dose in Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. Published 1 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →