Hemodynamics, fluids & transfusion
Exploratory clinical trial on the acoustic variability index for predicting fluid responsiveness during hepatectomy
Authors' conclusion
Real-time intraoperative monitoring of the AVI shows potential as a predictor for fluid responsiveness in patients undergoing hepatectomy.
Study context
- Population
- Adults undergoing hepatectomy, 500 mL crystalloid fluid challenge after major resection and stabilisation; responders = ≥ 10% increase in cardiac output (CO)37 analysed
- Participants
- Forty adults
- Comparison
- Acoustic variability index (AVI) vs central venous pressure (CVP), stroke volume variation (SVV) and PPV for predicting fluid responsiveness
- Outcome
- Ability of AVI to predict fluid responsiveness (≥ 10% increase in CO after 500 mL crystalloid)
Methodological detailssingle-centre, exploratory
- Single-centre
- Exploratory
Performance
As reported in the abstract
Prediction of fluid responsiveness
| Test or model | AUC | Optimal cutoff |
|---|---|---|
| AVI | 0.873 (95% CI: 0.743-0.967) | > 9.8% |
AVI
AUC0.873 (95% CI: 0.743-0.967)
Optimal cutoff> 9.8%
Further findings
Responders
- Responders
- 12 (32.4%)
Change in AVI after fluid loading, responders
- Significant decrease, 11.4% ± 2.5% to 7.8% ± 2.9%
- P = 0.004
Change in AVI after fluid loading, non-responders
- No significant change, 7.1% ± 3.2% to 6.3% ± 3.0%
- P = 0.356
Original publication
Exploratory clinical trial on the acoustic variability index for predicting fluid responsiveness during hepatectomy. J Clin Monit Comput. Published 9 March 2026. doi:10.
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