Perioperative medicine & outcomes
Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials
Authors' conclusion
Most critical care RCTs do not examine for subgroup effects by frailty or multimorbidity. Although age is more commonly considered, the cut-point is variable, and relative effect modification is rare.
Study context
- Population
- Randomized controlled trials (RCTs) of critical care interventions in the ICU reporting age, frailty or multimorbidity subgroups, published 2011–2021
- Participants
- 50,779 participants · 48 RCTs
- Comparison
- Effect modification of ICU interventions by age, frailty or multimorbidity subgroups
- Outcome
- Statistically significant effect modification by subgroup
Methodological detailscredibility of subgroup findings assessed with ICEMAN instrument
- Credibility of subgroup findings assessed with ICEMAN instrument
Pooled result
As reported in the abstract
- RCTs with significant effect modification by age
- Seven (14.6%)
- Multimorbidity or frailty subgroups with significant subgroup effect
- 0
- Subgroup credibility
- very low to moderate
Original publication
Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials. Crit Care Med. Published 25 April 2024. doi:10.
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