Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis
Authors' conclusion
Short and long-term exposures to ambient SO2, PM2.5, and NO2 are associated with increased ARDS risk in sepsis
Study context
- Population
- Critically ill patients with sepsis
- Participants
- 1,858 patients
- Exposure
- Higher vs lower short-, medium- and long-term exposure to ambient air pollutants (75th vs 25th percentile)
- Outcome
- ARDS by the Berlin Criteria
- Follow-up
- 6 days
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Main finding
As reported in the abstract
ARDS risk per pollutant (long-term exposure, 75-25th percentile)
75th percentile vs 25th percentileOdds ratio (95% CI)P value
SO2
1.43(1.16–1.77)
P < 0.01NO2
1.36(1.06–1.74)
P = 0.04PM2.5
1.21(1.04–1.41)
P = 0.03- Acute respiratory distress syndrome (ARDS) developed in all subjects
- 754 (41%)
Observational data: associations, not effects.
Further findings
Plasma inflammatory proteins (764 subjects)
- Long-term exposures to SO2, NO2 and PM2.5 associated with plasma interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor-1 concentrations
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis. Intensive Care Med. Published 20 July 2023. doi:10.
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