External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock
Authors' conclusion
The sRAI affords more accurate and specific prediction than context-free SCr elevation or the original RAI in this population.
Study context
- Population
- Children with septic shock admitted to the PICU, 1/2019 to 12/2022
- Participants
- 140 / 195 / 253
- Comparison
- sRAI + vs renal angina index (RAI) + vs D1 SCr > Baseline +
- sRAI +n = 140
- RAI +n = 195
- D1 SCr > Baseline +n = 253
- Primary endpoint
- Severe AKI (≥ KDIGO Stage 2)
- Follow-up
- Day 3
Methodological detailsdiagnostic accuracy / prediction, external validation
- Diagnostic accuracy / prediction
- External validation
Primary result
As reported in the abstract
D3 severe AKI prediction
sRAI +
- AUROC
- 0.86 (95%CI 0.82-0.90)
- Specificity
- 74%
RAI +
58%
specificity
D1 SCr > Baseline +
36%
specificity
sRAI + vs sRAI-Estimate (95% CI)P value
D3 severe AKI prediction
RR 8.9(5–16)
P < 0.001Multivariable regression
aOR 4.5(2.0–10.2)
P < 0.001- D3 severe acute kidney injury (AKI) incidence
- 79 (22%)
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| KRTsRAI + vs sRAI- | RR 18 (95% CI 6.6–49) | P < 0.001 | |
| KRTsRAI + vs sRAI- · multivariable regression | aOR 5.6 (95% CI 1.5–21.5) | P = 0.01 | |
| MortalitysRAI + vs sRAI- | RR 2.5 (95% CI 1.2–5.5) | P = 0.013 | |
| 0.050.21520Ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock. Crit Care. Published 28 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →