Clinical utility of proenkephalin A 119-159 for prediction of worsening renal function and prognosis in patients with sepsis –results of a patient-level meta-analysis
Pooled result · WRFResult — go to the resultOdds ratio 3.4 95% CI 2.7–4.3Authors' conclusion
penKid adds predictive value beyond sCr for identifying patients at risk for WRF and 28d-mortality. Importantly, elevated penKid identifies at-risk patients even when sCr is normal.
Study context
- Population
- ICU patients with sepsis or septic shock (RCTs or observational trials, >100 patients per study)
- Participants
- 2,203 patients · 4 studies
- Comparison
- Elevated vs normal penKid
- Outcome
- Worsening renal function (WRF): further sCr increase ≥0.3 mg/dL from ICU admission value, or need for renal replacement therapy (RRT), or death
- Follow-up
- 48 h
Methodological detailsretrospectively registered, PubMed and internal resources searched in March 2025
- Retrospectively registered
- PubMed and internal resources searched in March 2025
Pooled result
WRF
Odds ratio
3.4
95% CI 2.7–4.3
P < 0.0001
Elevated vs normal penKid
OR 3.4 (95% CI 2.7–4.3); P < 0.0001
As reported in the abstract
Further pooled results
28d-mortality · 28 days
| OR (95% CI) | P value | ||
|---|---|---|---|
| penKidIndependent association | 1.6 (1.4–1.9) | P < 0.0001 | |
| 0.512Odds ratio (log scale) |
WRF, subgroup with normal sCr at admission · 48 h
P < 0.0001
28d-mortality, subgroup with normal sCr at admission · 28 days
P < 0.0001
Original publication
Clinical utility of proenkephalin A 119-159 for prediction of worsening renal function and prognosis in patients with sepsis –results of a patient-level meta-analysis. Crit Care. Published 24 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →