The Prevalence and Prognostic Implications of Elevated Pulmonary Vascular Resistance in Septic Patients
Authors' conclusion
In septic patients, the combination of elevated PVR and RVSD was an independent predictor of 30-day mortality. However, neither PVR elevation nor RVSD alone was significantly associated with 30-day mortality.
Study context
- Population
- Septic patients in a tertiary hospital ICU
- Participants
- 638 patients
- Exposure
- RV systolic dysfunction (RVSD) and/or pulmonary vascular resistance (PVR) elevation vs normal right ventricular (RV) function
- Normal RV functionn = 205reference
- Isolated RVSDn = 76
- Isolated PVR elevationn = 195
- RVSD + PVR elevationn = 162
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Each group vs normal RV functionHazard ratio (95% CI)P value
RVSD + PVR elevationCox regression, independent association
2.907(1.385–6.100)
P = 0.005Isolated RVSD
0.617(0.168–2.274)
P = 0.468Isolated PVR elevation
1.074(0.469–2.461)
P = 0.865Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| 30-day mortality, PVR >2.0 vs ≤2.0 WU, patients with RVSD (subgroup) | 3.878 (1.139–13.203) | P = 0.030 | |
| 30-day mortality, PVR >2.0 vs ≤2.0 WU, normal RV systolic function (subgroup) | 1.632 (0.793–3.358) | P = 0.183 | |
| 0.050.21520Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Prevalence and Prognostic Implications of Elevated Pulmonary Vascular Resistance in Septic Patients. J Cardiothorac Vasc Anesth. Published 8 June 2025. doi:10.
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