Time Course of Morbidity and Mortality Across Echocardiographic Phenotypes in Patients With Sepsis: A Systematic Review and Meta-Analysis
Authors' conclusion
This meta-analysis shows a parabolic-like pattern of the occurrence rate of echocardiographic phenotypes (LVSD, LVDD, and RVD) over the time course of sepsis. LVSD, LVDD, and RVD are significant risk factors for mortality in sepsis.
Study context
- Population
- Adults with sepsis and new-onset myocardial dysfunction diagnosed by echocardiography
- Participants
- 17,008 adults · 65 studies
- Comparison
- Echocardiographic phenotypes of new-onset myocardial dysfunction (left ventricular systolic dysfunction (LVSD), left ventricular diastolic dysfunction (LVDD), right ventricular dysfunction (RVD)) over the time course of sepsis
- Outcome
- Temporal evolution of morbidity (occurrence rate) and mortality across echocardiographic phenotypes
Methodological detailssubgroups by echocardiographic time point
- Subgroups by echocardiographic time point
Pooled result
As reported in the abstract
Occurrence rate of phenotypes over time
- LVSD peak within 48 hours
- 33% (95% CI, 27-40%)
- LVSD within 72 hours
- 22% (95% CI, 18-25%)
- LVDD within 48 hours
- 46% (95% CI, 34-57%)
- LVDD within 72 hours
- 44% (95% CI, 32-56%)
- RVD peak within 48 hours
- 47% (95% CI, 37-58%)
- RVD within 72 hours
- 33% (95% CI, 3-75%)
Further pooled results
Risk of death by phenotype
| RR (95% CI) | P value | ||
|---|---|---|---|
| LVSD | 1.57 (1.29–1.91) | P < 0.0001 | |
| LVDD | 1.36 (1.05–1.75) | P = 0.02 | |
| RVD | 1.62 (1.35–1.95) | P < 0.0001 | |
| 0.512Relative risk (log scale) |
Original publication
Time Course of Morbidity and Mortality Across Echocardiographic Phenotypes in Patients With Sepsis: A Systematic Review and Meta-Analysis. Crit Care Med. Published 25 August 2025. doi:10.
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