Early high-sensitivity troponin elevation and short-term mortality in sepsis: a systematic review with meta-analysis
Authors' conclusion
Non-survivors of sepsis exhibited significantly elevated hs-cTn levels. While elevated hs-cTn levels are associated with an increased risk of mortality, they are not independently associated with this outcome in sepsis.
Study context
- Population
- Adults with sepsis meeting the Sepsis-3 definition
- Participants
- 6,242 adults · 17 studies
- Comparison
- Elevated vs normal early hs-cTn
- Outcome
- Short-term mortality
Methodological detailsrandom effect models, PubMed, Scopus and Embase search
- Random effect models
- PubMed, Scopus and Embase search
Pooled result
As reported in the abstract
Elevated hs-cTn vs Normal hs-cTnEstimate (95% CI)
Unadjusted
OR 1.78(1.41–2.25)
Studies adjusting for confounders
aOR 1.06(0.99–1.14)
Further pooled results
| Outcome | SMD (95% CI) | |
|---|---|---|
| hs-cTn level, non-survivors vs survivors (crude analysis)Crude | 0.87 (0.41–1.33) | |
| −1012Difference (linear scale) |
Original publication
Early high-sensitivity troponin elevation and short-term mortality in sepsis: a systematic review with meta-analysis. Crit Care. Published 14 February 2025. doi:10.
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