The Association Between Elevated Myocardial Injury-Related Biomarker (Troponin I (TnI)) and Increased Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome*
Authors' conclusion
Elevated TnI levels were prevalent among patients with SFTS and were strongly associated with an increased risk of mortality.
Study context
- Population
- Patients with severe fever with thrombocytopenia syndrome (SFTS), Union Hospital, Wuhan, China, May 2014–December 2021
- Participants
- 580 patients
- Exposure
- Elevated vs normal troponin I and mortality
- Survivorsn = 469
- Nonsurvivorsn = 111
- Outcome
- Myocardial injury (TnI elevation) and mortality
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- 21-day fatality rate
- 19.1%
- TnI elevation on admission (357/580)
- 61.6%
- Abnormal TnI during hospitalization (397/580)
- 68.4%
- Mortality with TnI ≥10 times upper limit of normal at admission
- 43.8%
- Mortality with TnI ≥10 times upper limit of normal during hospitalization
- 41.7%
Observational data: associations, not effects.
Further findings
- Older age, history of CVD and higher d-dimer potential risk factors for elevated TnI
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Association Between Elevated Myocardial Injury-Related Biomarker (TnI) and Increased Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome*. Crit Care Med. Published 28 June 2024. doi:10.
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