Cardiac arrest & resuscitation
Extracorporeal cardiopulmonary resuscitation for adult out-of-hospital cardiac arrest patients: time-dependent propensity score-sequential matching analysis from a nationwide population-based registry
Main findingResult — go to the resultRelative risk 1.28 95% CI 0.85–1.93Authors' conclusion
ECPR itself was not associated with good neurological recovery, but early ECPR was positively associated with good neurological recovery.
Study context
- Population
- Adult medical out-of-hospital cardiac arrest (OHCA) patients who underwent CPR at the ED, nationwide OHCA registry, 2013–2020484 received ECPR
- Participants
- 118,391 patients
- Exposure
- ECPR vs no ECPR within the same time interval
- ECPRn = 458
- No ECPRn = 1,832reference
- Outcome
- Good neurological recovery
- Follow-up
- Discharge
Methodological detailstime-dependent propensity-score matched, 1:4 matching, nationwide population-based registry
- Time-dependent propensity-score matched
- 1:4 matching
- Nationwide population-based registry
Main finding
As reported in the abstract
Relative risk
1.28
95% CI 0.85–1.93
By group
ECPR vs no ECPR
RR 1.28 (95% CI 0.85–1.93)
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Good neurological recovery by timing of ECPR pump-on after ED arrival (stratified analysis)ECPR vs no ECPR · 1-30 min | 2.51 (1.33–4.75) | |
| Good neurological recovery by timing of ECPR pump-on after ED arrival (stratified analysis)ECPR vs no ECPR · 31-45 min | 1.81 (1.11–2.93) | |
| Good neurological recovery by timing of ECPR pump-on after ED arrival (stratified analysis)ECPR vs no ECPR · 46-60 min | 1.07 (0.56–2.04) | |
| Good neurological recovery by timing of ECPR pump-on after ED arrival (stratified analysis)ECPR vs no ECPR · over 60 min | 0.45 (0.11–1.91) | |
| 0.10.31310Relative risk (log scale) |
Original publication
Extracorporeal cardiopulmonary resuscitation for adult out-of-hospital cardiac arrest patients: time-dependent propensity score-sequential matching analysis from a nationwide population-based registry. Crit Care. Published 6 March 2023. doi:10.
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