Extracorporeal Life Support Use During Severe Anaphylaxis: A Systematic Review and Pooled Analysis of Individual Patient Data
Authors' conclusion
ECLS may provide meaningful survival and neurologic benefits in severe anaphylaxis, though complications are frequent and evidence remains limited.
Study context
- Population
- Patients hospitalized due to anaphylactic shock receiving extracorporeal life support (ECLS)
- Participants
- 78 patients · 50 studies
Methodological detailsBayesian mixed-effects logistic regression, GRADE certainty assessment
- Bayesian mixed-effects logistic regression
- GRADE certainty assessment
Pooled result
As reported in the abstract
Pooled survival rate
85.9%
95% CI 77.0–92.9
Favorable neurologic outcomes in survivors
86.3%
95% CI 77.5–93.8
Further pooled results
Patient characteristics
- Venoarterial ECMO
- 72%
- Underwent CPR
- 53%
- Medications as trigger
- 60.2%
Safety
- Complication rate
- 11.0% (95% CI 2.4-21.9)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Extracorporeal Life Support Use During Severe Anaphylaxis: A Systematic Review and Pooled Analysis of Individual Patient Data. J Cardiothorac Vasc Anesth. Published 9 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →