Factors affecting voriconazole pharmacokinetic variability in critically ill patients: a systematic review
Study context
- Population
- Critically ill (intensive care unit (ICU)) patients receiving voriconazole31 studies
- Outcome
- Factors associated with variability of voriconazole Ctrough
Methodological detailsMEDLINE, Web of Science and Cochrane Library searched from inception through July 2025
- MEDLINE, Web of Science and Cochrane Library searched from inception through July 2025
Pooled result
As reported in the abstract
Factors of variability of voriconazole exposure
- Liver dysfunction, high BMI, high SOFA score and high inflammation status associated with voriconazole overexposure
- Oral route, RRT and low BMI associated with voriconazole underexposure
- Effects of ECMO and hypoalbuminemia on voriconazole exposure unclear
- 9 factors of variability described
Original publication
Factors affecting voriconazole pharmacokinetic variability in critically ill patients: a systematic review. Crit Care. Published 25 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →