Neuroanesthesia & neurocritical care
Factors associated with acute respiratory distress syndrome in brain-injured patients: A systematic review and meta-analysis
Authors' conclusion
Multiple risk factors are associated with ARDS in brain-injured patients.
Study context
- Population
- Adults with acute brain injury
- Participants
- 6,961,284 adults · 23 studies
- Outcome
- Factors associated with ARDS
Methodological detailsGRADE certainty assessment
- GRADE certainty assessment
Pooled result
As reported in the abstract
Factors associated with ARDS (adjusted analysis)
Odds ratio (95% CI)
Sepsishigh certainty
4.38(2.37–8.10)
History of hypertensionhigh certainty
3.11(2.31–4.19)
Pneumoniahigh certainty
2.69(2.35–3.10)
AKImoderate certainty
1.44(1.30–1.59)
Admission hypoxemiamoderate certainty
1.67(1.29–2.17)
Male sexmoderate certainty
1.30(1.06–1.58)
COPDmoderate certainty
1.27(1.13–1.44)
Further pooled results
In-hospital mortality with acute respiratory distress syndrome (ARDS)
| OR (95% CI) | ||
|---|---|---|
| ARDSIndependently associated | 3.12 (1.39–7.00) | |
| 0.10.31310Odds ratio (log scale) |
Pooled cumulative incidence of ARDS after brain injury
- Cumulative incidence of ARDS
- 17.0% (95%CI 10.7-25.8)
Original publication
Factors associated with acute respiratory distress syndrome in brain-injured patients: A systematic review and meta-analysis. J Crit Care. Published 24 May 2023. doi:10.
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