Neuroanesthesia & neurocritical care
Feasibility of Prone Positioning for Brain-injured Patients with Severe Acute Respiratory Distress Syndrome: A Systematic Review and Pilot Study (ProBrain)
Authors' conclusion
Brain-injured patients are largely excluded from studies evaluating prone position in acute respiratory distress syndrome. However, cerebral blood flow seems not to be altered considering increasing of mean arterial pressure during the session.
Study context
- Population
- Brain-injured patients with severe ARDS needing prone positionpilot study
- Participants
- 11 patients
- Comparison
- Before vs during prone position
- Outcome
- Cerebral blood flow by transcranial Doppler after prone positioning
Methodological detailsconsecutive patients
- Consecutive patients
Pooled result
As reported in the abstract
Diastolic speed, right side, range before and during prone (mean ± SD), P = 0.897
37.7 ± 16.2 cm/s to 45.2 ± 19.3 cm/s
Diastolic speed, left side, range before and during prone (mean ± SD), P = 0.569
39.6 ± 18.2 cm/s to 46.5 ± 21.3 cm/s
Pulsatility index, right side, range before and during prone, P = 0.145
1.14 ± 0.31 to 1.0 ± 0.32
Pulsatility index, left side, range before and during prone, P = 0.564
1.14 ± 0.31 to 1.02 ± 0.2
Further pooled results
Systematic review: exclusion of brain-injured patients from prone position ARDS studies
- Studies included (of 8,183 citations)
- 120
- Studies excluding brain-injured patients without justification
- 90 (75%)
- Studies including brain-injured patients (4 randomized, 7 nonrandomized, 5 retrospective)
- 16
- Studies not retrieving brain-injured data
- 14
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →