Respiratory failure & ventilation
Prognostic Factors Associated With Extubation Failure in Acutely Brain-Injured Patients: A Systematic Review and Meta-Analysis*
Authors' conclusion
Patient age, duration of mechanical ventilation, and airway reflexes were associated with extubation failure in brain-injured patients with moderate certainty.
Study context
- Population
- Acutely brain-injured adults receiving invasive ventilation ≥24 hours in an ICU21 studies
- Comparison
- Prognostic factors for extubation failure
- Outcome
- Extubation failure (pooled aOR for each prognostic factor)
Methodological detailsrandom-effects models, GRADE certainty assessment, QUIPS risk of bias, 7,626 citations screened; 21 studies met selection criteria
- Random-effects models
- GRADE certainty assessment
- QUIPS risk of bias
- 7,626 citations screened; 21 studies met selection criteria
Pooled result
As reported in the abstract
Extubation failure
Adjusted odds ratio (95% CI)
Older age (upper vs lower tertile)
3.0(1.78–5.07)
Longer duration of mechanical ventilation (upper vs lower tertile)
3.47(1.68–7.19)
Presence of cough
0.40(0.28–0.57)
Intact swallow
0.34(0.21–0.54)
Original publication
Prognostic Factors Associated With Extubation Failure in Acutely Brain-Injured Patients: A Systematic Review and Meta-Analysis*. Crit Care Med. Published 30 December 2022. doi:10.
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