Paediatric anaesthesia & critical care
Factors Impacting Outcomes of Peripheral Nerve Blockade in Children With Charcot–Marie–Tooth Disease Undergoing Foot Surgery
Authors' conclusion
In this pediatric CMT cohort, no permanent neurologic complications potentially attributable to PNB were observed.
Study context
- Population
- Children <18 years with genetically confirmed charcot-Marie-Tooth (CMT) undergoing foot surgery with peripheral nerve blockade (PNB), 2017–202322 operative sessions · 24 limbs
- Participants
- 15 children
- Outcome
- New or worsened postoperative neurologic deficits potentially attributable to PNB
Methodological detailsquality-improvement initiative, exploratory genotype comparisons
- Quality-improvement initiative
- Exploratory genotype comparisons
Main finding
As reported in the abstract
Postoperative neurologic deficits
Limbs with transient postoperative neurologic deficits
2
8%
Permanent neurologic complications potentially attributable to PNB
0
Observational data: associations, not effects.
Secondary outcomes
| Outcome | P value |
|---|---|
| Neurologic deficits and prolonged block by genotype (CMT1F subgroup, 4 patients)CMT1F · exploratory | P = 0.057 |
| Neurologic deficits and prolonged block by genotype (CMT1F subgroup, 4 patients)CMT1F · exploratory | P = 0.0037 |
- Neurologic deficits and prolonged block by genotype (CMT1F subgroup, 4 patients): neurologic deficits more frequent; exploratory patient-level analysis
- Neurologic deficits and prolonged block by genotype (CMT1F subgroup, 4 patients): prolonged block more frequent; exploratory patient-level analysis
Postoperative pain scores · first 72 postoperative hours
- Generally low and decreased over the first 72 postoperative hours
Low-dose opioid use · within 72 h
- Operative sessions with low-dose opioid use
- 11/22 (50%)
Prolonged block duration
- Limbs with prolonged block duration
- 7 (29%)
Safety
Transient postoperative neurologic deficits
- Limbs affected
- 2 (8%)
Original publication
Factors Impacting Outcomes of Peripheral Nerve Blockade in Children With Charcot–Marie–Tooth Disease Undergoing Foot Surgery. Paediatr Anaesth. Published 20 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →