Pediatric anesthesia & critical care
Regional anesthesia and sickle cell crisis in pediatric patients: An educational‐focused review
Authors' conclusion
The available literature, albeit all retrospective or anecdotal, suggests the potential utility of regional anesthesia to treat pain in patients with SCD.
Study context
- Population
- Pediatric patients with sickle cell disease and vaso-occlusive (pain) crisis7 + 4 publications
- Comparison
- Neuraxial anesthesia vs Peripheral blockade
- Neuraxial anesthesian = 26
Methodological detailseducational-focused review, retrospective case series and case reports
- Educational-focused review
- Retrospective case series and case reports
Pooled result
As reported in the abstract
- Neuraxial anesthesia: 7 publications (retrospective case series or single case reports), 26 patients with sickle cell disease (SCD)
- Peripheral blockade: 4 publications (1 retrospective case series, 3 single case reports) in patients with VOC and SCD
- Literature suggests potential utility of RA to treat pain in SCD
- Avoidance of potential deleterious physiologic effects of systemic opioids
- Improved respiratory function by pulse oximetry (one case series)
- All evidence retrospective or anecdotal; no prospective trials
Original publication
Regional anesthesia and sickle cell crisis in pediatric patients: An educational‐focused review. Paediatr Anaesth. Published 20 November 2023. doi:10.
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