Pediatric anesthesia & critical care
Factors associated with adverse outcome among children with sickle cell disease admitted to the pediatric intensive care unit: an observational cohort
Authors' conclusion
Baseline hemoglobin < 8 g/dL, history of bronchial obstruction and admission for ACS were the strongest risk factors for severe evolution in SCD children admitted to PICU.
Study context
- Population
- Children with sickle cell disease (SCD) admitted to Pediatric Intensive Care Units (PICU) for acute crisis, tertiary hospital in France, 2009–2019
- Participants
- 395 children · 579 admissions
- Outcome
- Adverse outcome (death during stay and/or invasive MV and/or NIV >3 days and/or vasopressors and/or RRT)
Methodological detailssingle-centre, tertiary hospital, consecutive admissions
- Single-centre
- Tertiary hospital
- Consecutive admissions
Main finding
As reported in the abstract
Adverse outcome
Admissions with adverse outcome
113
20%
Observational data: associations, not effects.
Further findings
Hydroxyurea treatment or exchange transfusion program
- No difference between patients with adverse outcome and other patients
Reasons for admission
- Acute chest syndrome (ACS)
- 331, 57%
- Vaso-occlusive crisis refractory to first line therapy
- 99, 17%
Life-sustaining therapies and PICU course
- Required non-invasive ventilation (NIV)
- Half of patients
- Required mechanical ventilation (MV)
- 47 (8%)
- Overall LOS, days
- 3 [1-4]
- Died during PICU stay
- 7 (1%)
Original publication
Factors associated with adverse outcome among children with sickle cell disease admitted to the pediatric intensive care unit: an observational cohort. Ann Intensive Care. Published 10 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →