Pediatric anesthesia & critical care
Perioperative Outcomes and Sickle Cell Crisis in Children With Sickle Cell Disease: A Retrospective Observational Study
Authors' conclusion
The perioperative course in children with SCD was associated with longer postoperative length of stay and higher blood transfusion rates relative to those without SCD undergoing similar surgical procedures. Perioperative sickle cell crisis was present in more than one out of six admissions, more common in non-elective admissions, and is associated with excess length of stay.
Study context
- Population
- Children < 18 years admitted for cholecystectomy, appendectomy, congenital cardiac surgery or posterior spinal fusion, Healthcare Cost and Utilization Project (HCUP) Kids' Inpatient Database (KID) 2003–2019
- Exposure
- Sickle cell disease (SCD) vs No SCD
- SCDn = 2,357
- Outcome
- Perioperative outcomes: post-operative length of stay (LOS), blood transfusions, hematologic and infectious complications
Methodological detailsmultivariable Poisson regression, HCUP Kids' Inpatient Database (KID) 2003-2019
- Multivariable Poisson regression
- HCUP Kids' Inpatient Database (KID) 2003-2019
Main finding
As reported in the abstract
SCD vs No SCDEstimate (95% CI)P value
Post-operative LOS
aIRR 1.29(1.26–1.32)
P < 0.001Blood transfusion
aRR 13.1(12.1–14.2)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | SCD | Estimate | P value | |
|---|---|---|---|---|
| Sickle cell crisis during hospitalization (SCD)Non-elective admissions vs Elective admissions | 17.5% | aOR 3.36 (95% CI 2.46–4.60) | P < 0.001 | |
| Post-operative LOS, sickle cell crisis vs no crisis (SCD) | aIRR 1.58 (95% CI 1.49–1.67) | |||
| 0.20.5125Ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Perioperative Outcomes and Sickle Cell Crisis in Children With Sickle Cell Disease: A Retrospective Observational Study. Paediatr Anaesth. Published 20 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →