Respiratory failure & ventilation
Feasibility and safety of ultra-low volume ventilation (≤ 3 ml/kg) combined with extra corporeal carbon dioxide removal (ECCO2R) in acute respiratory failure patients
Authors' conclusion
Ultra-low volume ventilation (≤ 3 ml/kg PBW) was feasible in 18 out of 45 sessions. Higher blood flow rates were associated with the success of ultra-low volume ventilation.
Study context
- Population
- Acute respiratory failure patients treated with high or low blood flow veno-venous ECCO2R45 ECCO2R sessions
- Participants
- 41 patients
- Exposure
- Success vs Failure
- Successn = 18
- Outcome
- Proportion of sessions with Vt ≤ 3 ml/kg PBW at 24 h after ECCO2R start, achieved for at least 12 h
- Follow-up
- 24 h
Main finding
As reported in the abstract
Ultra-low volume ventilation achieved (sessions)
Sessions achieving Vt ≤ 3 ml/kg predicted body weight (PBW): 18 out of 45 sessions, CI 25.3-54.6%
40.0%
Observational data: associations, not effects.
Secondary outcomes
Tidal volume, failure vs success sessions · 24 h · spread printed in brackets; kind not named in the abstract
P < 0.001
| Outcome | Adjusted OR of achieving ultra-low volume ventilation (success) (95% CI) | P value | |
|---|---|---|---|
| Blood flow rate and success of ultra-low volume ventilation (Vt ≤ 3 ml/kg PBW) (multivariate analysis)Higher odds of success | 1.51 (1.21–1.90) | P = 0.0003 | |
| 0.512Adjusted OR of achieving ultra-low volume ventilation (success) (log scale) |
Original publication
Feasibility and safety of ultra-low volume ventilation (≤ 3 ml/kg) combined with extra corporeal carbon dioxide removal (ECCO2R) in acute respiratory failure patients. Crit Care. Published 27 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →