Respiratory failure & ventilation
Impact of ultra-low tidal volume ventilation on 1-year functional outcome in COVID-19 acute respiratory distress syndrome (ARDS) patients. A long-term follow-up analysis of a randomized controlled trial
Primary result · MoCA 5-minute, SF-36 and IES-R scoresResult — go to the resultMedian difference −2 points 95% CI −4-0Authors' conclusion
ULTV is associated with a small but significant decrease in cognitive status at day-365 possibly related to exposure to higher PaCO2.
Study context
- Population
- COVID-19 ARDS patients with PaO2/fraction (FiO2) ≤ 150 mmHg in ten French ICUs7 lost to follow-up
- Participants
- 215 patients
- Comparison
- Ultra-low tidal volume ventilation vs low VT ventilation
- ULTVn = 106
- LTVn = 109reference
- Primary endpoint
- Prespecified long-term secondary outcomes: MoCA 5-minute, SF-36 and IES-R scores
- Follow-up
- Day-365
Methodological detailslong-term follow-up, open-label, multicentre, superiority, modified ITT
- Long-term follow-up
- Open-label
- Multicentre
- Superiority
- Modified ITT
Primary result
MoCA 5-minute, SF-36 and IES-R scores
Median difference
−2 points
95% CI −4-0
P < 0.05
ULTV vs LTV
median difference −2 points (95% CI −4-0); P < 0.05
As reported in the abstract
Secondary outcomes
| Outcome | ULTV | LTV | HR (95% CI) | |
|---|---|---|---|---|
| Mortality (added a posteriori) · day-365 | 46% | 42% | 1.19 (0.79–1.80) | |
| 0.512Hazard ratio (log scale) |
- Mortality (added a posteriori): denominators 102 and 106
MoCA 5-minute score vs PaCO2/PaO2 exposure (post-hoc)
- Significantly associated with AUC or maximal PaCO2 during ARDS management
- P < 0.01
- Not associated with AUC or minimal PaO2
- Post-hoc analysis
Original publication
Impact of ultra-low tidal volume ventilation on 1-year functional outcome in COVID-19 ARDS patients. A long-term follow-up analysis of a randomized controlled trial. Crit Care. Published 14 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →