Neuroanesthesia & neurocritical care
Feasibility and safety of electrocorticography monitoring after acute brain injury to detect cortical spreading depolarisation, a prospective observational study in a neurological intensive care unit
Authors' conclusion
Monitoring SD with electrocorticography is feasible and safe in a neuro-ICU with no prior experience.
Study context
- Population
- Adults admitted to a neurological intensive care units (neuro-ICU) without SD monitoring experience with subarachnoid haemorrhage (SAH) or severe traumatic brain injury (TBI), monitored by electrocorticography
- Participants
- 20 adults
- Exposure
- SAH vs TBI
- SAHn = 12
- TBIn = 8
- Outcome
- Availability of a high-quality electrocorticography signal, with or without SD, for ≥12 h per patient
Methodological detailssingle-centre, feasibility and safety
- Single-centre
- Feasibility and safety
Main finding
As reported in the abstract
High-quality electrocorticography signal ≥12 h
Primary endpoint achieved (patients)
19
Monitoring duration, median [IQR]
6 days
4–9
Observational data: associations, not effects.
Further findings
Events
| Outcome | SAH | TBI |
|---|---|---|
| At least 1 SD observed | 6 | 4 |
- At least 1 SD observed — Overall
- 10 patients (50%)
Safety
Adverse events
- Cerebrospinal fluid leakage
- 1
- Local skin infection with a Spencer-type intracortical electrode
- 1
- EVD-related ventriculitis with a subdural Spencer-type electrode
- 1
Original publication
Feasibility and safety of electrocorticography monitoring after acute brain injury to detect cortical spreading depolarisation, a prospective observational study in a neurological intensive care unit. Anaesth Crit Care Pain Med. Published 13 November 2025. doi:10.
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