Fibrinolysis as a Causative Mechanism for Bleeding Complications on Extracorporeal Membrane Oxygenation: A Pilot Observational Prospective Study
Authors' conclusion
Contact activation induces fibrinolysis in ECMO patients, especially in patients experiencing bleeding.
Study context
- Population
- Patients undergoing venovenous and venoarterial extracorporeal membrane oxygenation (ECMO)214 ECMO days
- Participants
- 30 patients
- Exposure
- Bleeding vs nonbleeding patients on ECMO
- Outcome
- Longitudinal dynamics of fibrinolytic markers in the context of bleeding events
- Follow-up
- Before implantation, at 0, 6, and 12 h after implantation, and daily thereafter
Methodological detailspilot, longitudinal
- Pilot
- Longitudinal
Main finding
As reported in the abstract
Fibrinolytic marker dynamics
OR for bleeding events (95% CI)P value
tPA >0.304 nM
4.92(1.01–24.08)
P = 0.049- Bleeding vs Nonbleeding
- median D-dimer dynamics 1,080 vs. −440 ng/ml; P = 0.05
- Bleeding vs Nonbleeding
- median tPA dynamics 0.130 vs. 0.100 nM; P = 0.038
Observational data: associations, not effects.
Original publication
Fibrinolysis as a Causative Mechanism for Bleeding Complications on Extracorporeal Membrane Oxygenation: A Pilot Observational Prospective Study. Anesthesiology. Published 19 March 2024. doi:10.
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