Respiratory failure & ventilation
Fibrotic-Like Pulmonary Radiographic Patterns Are Not Associated With Adverse Outcomes in COVID-19 Chronic Critical Illness
Authors' conclusion
Approximately half of adults with COVID-19-associated chronic critical illness have fibrotic-like patterns that are associated with higher interleukin-6 levels at intubation. Fibrotic-like patterns are not associated with longer time to liberation from mechanical ventilation or worse 6-month survival.
Study context
- Population
- Adults hospitalized with COVID-19-related acute respiratory distress syndrome (ARDS) and chronic critical illness (> 21 d of mechanical ventilation, tracheostomy, survival to ICU discharge), March–May 2020had chest CT
- Participants
- 64 adults
- Exposure
- Fibrotic-like vs nonfibrotic CT patterns
- Outcome
- Fibrotic-like radiographic patterns on chest CT and their associations with clinical characteristics, biomarkers, time to ventilator liberation and 6-month survival
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Fibrotic-like patterns (reticulations and/or traction bronchiectasis)
55%
Interleukin-6 level on the day of intubation associated with fibrotic-like patterns
4.40
OR per quartile change; 95% CI 1.90–10.1
Observational data: associations, not effects.
Further findings
Chronic critical illness among adults with COVID-19-related ARDS
- Developed chronic critical illness (141 of 616)
- 23%
- Had a chest CT (64 of 141)
- 46%
Original publication
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