Respiratory failure & ventilation
ICU predictive factors of fibrotic changes following COVID-19 related ARDS: a RECOVIDS substudy
Authors' conclusion
In this large cohort of COVID-19 ARDS survivors, 36.8% exhibited FC at 6 months post-ICU discharge.
Study context
- Population
- COVID-19 ARDS survivors (Berlin ARDS criteria or high flow oxygen therapy) in 32 centres in France and Belgium, with follow-up 6 ± 1 months after ICU dischargeanalysed of 555 included
- Participants
- 440 survivors
- Outcome
- Presence of fibrotic changes (FC) at follow-up CT
- Follow-up
- 6 ± 1 months after ICU discharge
Methodological detailsobservational, multicentre, substudy of the RECOVIDS study
- Observational
- Multicentre
- Substudy of the RECOVIDS study
Main finding
As reported in the abstract
Presence of FC at follow-up CT
Analysed
36.8%
162 events
- Nomogram for predicting pulmonary fibrotic changes (FC), AUC
- 80.6% (95%CI 76.4-84.8)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Values |
|---|---|
| Predominant radiological patterns | Patients with FC 18.5% |
Predominant radiological patterns
- Late organizing pneumonia most common pattern overall; 30 of 162 with FC mainly anterior fibrosis compatible with post ventilatory changes
Original publication
ICU predictive factors of fibrotic changes following COVID-19 related ARDS: a RECOVIDS substudy. Ann Intensive Care. Published 4 November 2025. doi:10.
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