Fluid infusion during postpartum hemorrhage: a secondary analysis of the Obstetric Bleeding Study (OBS) Plus prospective observational study
Authors' conclusion
In this report, no patient required respiratory or renal support and median fluid resuscitation volume was approximately equal to blood loss.
Study context
- Population
- Patients with PPH and measured blood loss ≥ 1000 mL managed with a PPH care bundle incorporating bedside coagulation testing428 analysed
- Participants
- 495 patients
- Primary endpoint
- Ratio of clear fluid infused: blood loss
Methodological detailsplanned secondary analysis, Fluid resuscitation at the discretion of the clinical team; infusions from 1 h before to 1 h after PPH analysed, Between 2017 and 2019; 67/495 (13.5%) excluded for missing data
- Planned secondary analysis
- Fluid resuscitation at the discretion of the clinical team; infusions from 1 h before to 1 h after PPH analysed
- Between 2017 and 2019; 67/495 (13.5%) excluded for missing data
Primary result
As reported in the abstract
Ratio of clear fluids: blood loss
Overall median ratio clear fluids: blood loss
858:1000 mL
Further findings
Clear fluid infusions
- Crystalloid
- 426/428 (99.5%)
- Colloid
- 39/428 (9.1%)
- Fluid volumes ≥ 3500 mL only infused in massive PPH
Blood product transfusions
- RBC
- 40/428 (9.4%)
- FFP
- 3/428 (0.7%)
- Platelets
- 5/428 (1.1%)
Safety
- Patients requiring RRT or respiratory support for fluid overload
- 0
Original publication
Fluid infusion during postpartum hemorrhage: a secondary analysis of the Obstetric Bleeding Study (OBS) Plus prospective observational study. Int J Obstet Anesth. Published 26 January 2026. doi:10.
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