Frailty and outcomes after extracorporeal membrane oxygenation: a binational registry-based cohort study
Main finding · Adjusted one-year mortalityResult — go to the resultAdjusted risk difference +0.27% 95% CI −6.65% to +7.19%Authors' conclusion
Frailty was not associated with short or long-term mortality among patients who received ECMO.
Study context
- Population
- Adults (≥ 16 years) who received Extracorporeal Membrane Oxygenation (ECMO) in 116 Intensive Care Units (ICUs), Australia and New Zealand Intensive Care Society Adult Patient Database, 2018–2024
- Participants
- 2,084 adults
- Exposure
- Frailty vs no frailty
- Frailn = 254
- Without frailtyn = 1,830reference
- Outcome
- One-year mortality (assessed using g-computation)
- Follow-up
- One year
Methodological detailsbinational registry-based, multicentre (116 ICUs), g-computation
- Binational registry-based
- Multicentre (116 ICUs)
- G-computation
Main finding
Adjusted one-year mortality
Adjusted risk difference
+0.27%
95% CI −6.65% to +7.19%
Events by group
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
One-year mortality by principal diagnostic group (subgroup), risk difference
- Cardiac medical
- −7.87%
- Cardiac surgical
- + 3.70%
- Cardiac arrest
- −1.66%
- Respiratory
- + 10.02%
- Transplant
- + 2.19%
- Others
- −0.58%
Original publication
Frailty and outcomes after extracorporeal membrane oxygenation: a binational registry-based cohort study. Crit Care. Published 27 December 2025. doi:10.
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