Perioperative medicine & outcomes
FRailty in Australian patients admitted to Intensive care unit after eLective CANCER-related SURGery: a retrospective multicentre cohort study (FRAIL-CANCER-SURG study)
Main finding · Survival time up to 4 yr (lower survival = higher hazard)Result — go to the resultHR, event not clearly stated (lower survival) 1.72 95% CI 1.59–1.86Authors' conclusion
Frailty was associated with poorer outcomes after an ICU admission after elective surgery for cancer, particularly in the short term.
Study context
- Population
- Adults ≥16 yr admitted to 158 ICUs in Australia after elective surgery for cancer, January 1, 2018 to March 31, 2022
- Participants
- 35,848 adults · 158 ICUs
- Exposure
- Frail vs not frail
- Frailn = 3,502
- Outcome
- Survival time
- Follow-up
- Up to 4 yr
Methodological detailsmulticentre, Median follow-up 18.1 months (IQR 8.3-31.1)
- Multicentre
- Median follow-up 18.1 months (IQR 8.3-31.1)
Main finding
As reported in the abstract
Survival time up to 4 yr (lower survival = higher hazard)
HR, event not clearly stated (lower survival)
1.72
95% CI 1.59–1.86
Frail vs CFS ≤4
HR, event not clearly stated (lower survival) 1.72 (95% CI 1.59–1.86)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortality early in follow-up · up to 10 months | 1.39 (1.03–1.86) | |
| Mortality, late follow-up · up until 4 yrPredictive capacity diminished with time | 1.96 (0.73–5.28) | |
| 0.20.5125Hazard ratio (log scale) |
Subgroups by age (<65, 65-80, ≥80 yr) and hospital survivors (subgroup)
- Frailty associated with similar effects when stratified by age and in those who survived hospitalisation
Original publication
FRailty in Australian patients admitted to Intensive care unit after eLective CANCER-related SURGery: a retrospective multicentre cohort study (FRAIL-CANCER-SURG study). Br J Anaesth. Published 19 February 2024. doi:10.
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