Perioperative medicine & outcomes
Functional brain network and trail making test changes following major surgery and postoperative delirium: a prospective, multicentre, observational cohort study
Authors' conclusion
Postoperative delirium was associated with decreased brain functional connectivity strength after 3 months, suggesting that delirium has a long-lasting impact on brain networks. The decreased connectivity strength was associated with significant cognitive deterioration after major surgery.
Study context
- Population
- Older patients undergoing elective major surgery with clinical assessments (incl. TMT-B) and resting-state functional MRI before and 3 months after surgery246 analysed after motion correction
- Participants
- 554 patients
- Exposure
- Postoperative delirium vs no postoperative delirium
- Postoperative deliriumn = 38
- Outcome
- Change in resting-state functional MRI (rs-fMRI) functional connectivity strength
- Follow-up
- 3 months after surgery
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
As reported in the abstract
β
0.006
95% CI 0.001–0.011P = 0.013
Total study population · increase after surgery
β
−0.015
95% CI −0.028 to 0.002P = 0.023
Postoperative delirium vs No postoperative delirium · decrease after postoperative delirium
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) | P value |
|---|---|---|
| TMT-B decline in patients with decreased vs not decreased functional connectivity strength | 11.04 (0.85–21.2) | P = 0.034 |
TMT-B scores, delirium vs no delirium · follow-up
- No difference in TMT-B scores between patients with and without postoperative delirium
Original publication
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