Perioperative medicine & outcomes
Metabolic syndrome and the risk of postoperative delirium and postoperative cognitive dysfunction: a multi-centre cohort study
Authors' conclusion
Older surgical patients with metabolic syndrome were at increased risk of POD. Only reduced HDL-C was significantly associated with POD. For POCD, a higher preoperative BMI was identified as a risk factor.
Study context
- Population
- Male and female surgical patients aged ≥65 years520 attended at 3 months
- Participants
- 765 participants
- Exposure
- Metabolic syndrome and its components and risk of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD)
- Outcome
- POD (screened for 7 days or until discharge) and POCD (cognitive change on six neuropsychological tests vs non-surgical controls)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
POD and POCD
- POD incidence
- 149 (19.5% of 765)
- POCD incidence at 3 months
- 53 (10.1% of 520 attendees)
- Metabolic syndrome: risk of POD, 1.85-fold higher
- 1.85 (95% CI 1.26-2.70)
- Per 1 mM higher high-density lipoprotein cholesterol (HDL-C): POD risk 0.47-fold
- 0.47 (95% CI 0.30-0.74)
- Per 1 kg m-2 higher body mass index (BMI): POCD risk 1.09-fold higher
- 1.09 (95% CI 1.02- 1.16)
Observational data: associations, not effects.
Original publication
Metabolic syndrome and the risk of postoperative delirium and postoperative cognitive dysfunction: a multi-centre cohort study. Br J Anaesth. Published 20 June 2023. doi:10.
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