Perioperative medicine & outcomes
General anaesthesia versus monitored anaesthesia care and postoperative outcome in patients with elevated right ventricular systolic pressure undergoing low-risk surgical procedures: a retrospective single-centre cohort study
Main finding · Composite of AKI, acute myocardial injury or 30-day mortality (major complications)Result — go to the resultOdds ratio 1.24 95% CI 1.02–1.51Authors' conclusion
After adjustment for preoperative risk and evaluating intraoperative mediators, we found no evidence of a statistically significant difference in major postoperative complications between general anaesthesia and monitored anaesthesia care in adults with elevated RVSP undergoing low-risk procedures.
Study context
- Population
- Adults with right ventricular systolic pressure (RVSP) >50 mm Hg undergoing low-risk procedures (endoscopy, bronchoscopy, catheterisation laboratory interventions, peripheral surgeries)
- Participants
- 4,962 adults
- Exposure
- GA vs MAC
- General anaesthesian = 2,473
- Monitored anaesthesia caren = 2,489reference
- Outcome
- Composite of:
- AKI
- Acute myocardial injury
- 30-day mortality
Methodological detailssingle-centre, inverse probability of treatment weighting, multivariable logistic regression
- Single-centre
- Inverse probability of treatment weighting
- Multivariable logistic regression
Main finding
As reported in the abstract
Composite of:
- AKI
- Acute myocardial injury
- 30-day mortality (major complications)
Odds ratio
1.24
95% CI 1.02–1.51
P = 0.030
General anaesthesia vs Monitored anaesthesia care
OR 1.24 (95% CI 1.02–1.51); P = 0.030
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Primary composite, adjusted for intraoperative factors (sensitivity analysis)GA vs MAC · anaesthesia duration, vasopressor use, fluid balance | 1.00 (0.81–1.23) | |
| 0.512Odds ratio (log scale) |
Interactions by emergency status or preoperative pulmonary hypertension-targeted therapy (subgroup)
- No significant interactions observed
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
General anaesthesia versus monitored anaesthesia care and postoperative outcome in patients with elevated right ventricular systolic pressure undergoing low-risk surgical procedures: a retrospective single-centre cohort study. BJA Open. Published 4 February 2026. doi:10.
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