Anaesthetic drugs & techniques
General Anaesthesia Versus Spinal Anaesthesia for Outpatient Total Hip and Knee Arthroplasty: A Randomised Trial Protocol
Study context
- Population
- Adults scheduled for outpatient primary total hip arthroplasty (THA) or total knee arthroplasty (TKA)
- Planned comparison
- General anaesthesia (GA) vs spinal anaesthesia (SA) for outpatient primary THA or TKA
- Primary endpoint
- Successful same-day discharge (discharge on the day of surgery) without readmission within 48 h after discharge
Methodological detailspragmatic, multicentre, parallel-group, superiority, 1:1 randomisation stratified by site and procedure (THA/TKA), group sequential design with O'Brien-Fleming boundaries for an interim analysis, Analyses will follow the ITT principle, Key secondary outcomes: time to fulfilment of hospital discharge indicators, quality-of-recovery (QoR-15) trajectories over postoperative Days 1-35, patients' qualitative experiences, cost per quality-adjusted life-year and safety (adverse events), Embedded qualitative study (semi-structured interviews) and economic evaluation from healthcare and societal perspectives
- Pragmatic
- Multicentre
- Parallel-group
- Superiority
- 1:1 randomisation stratified by site and procedure (THA/TKA)
- Group sequential design with O'Brien-Fleming boundaries for an interim analysis
- Analyses will follow the ITT principle
- Key secondary outcomes: time to fulfilment of hospital discharge indicators, QoR-15 trajectories over postoperative Days 1-35, patients' qualitative experiences, cost per quality-adjusted life-year and safety (adverse events)
- Embedded qualitative study (semi-structured interviews) and economic evaluation from healthcare and societal perspectives
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
General Anaesthesia Versus Spinal Anaesthesia for Outpatient Total Hip and Knee Arthroplasty: A Randomised Trial Protocol. Acta Anaesthesiol Scand. Published 15 June 2026. doi:10.
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