General anesthesia with intubation and emergency endoscopy outcomes in patients with upper gastrointestinal bleeding: an inverse probability of treatment weighting study
Main finding · Time to complete endoscopic hemostasisResult — go to the resultDifference −7.0 h 95% CI −11.5 to −2.6Authors' conclusion
In this study, GA with intubation for emergency upper GI endoscopy in patients with upper GI bleeding was associated with improved therapeutic efficiency and better tolerance, and not with increased adverse outcomes.
Study context
- Population
- Adults undergoing emergency upper gastrointestinal (GI) endoscopy for suspected upper GI bleeding, September 2020–December 2022; patients intubated for critical illness excluded
- Participants
- 195 adults
- Exposure
- General anesthesia (GA) with tracheal intubation vs no GA for emergency upper GI endoscopy
- GAn = 39
- non-GAn = 156reference
- Outcome
- Time to complete endoscopic hemostasis
Methodological detailssingle-centre, inverse probability of treatment weighting
- Single-centre
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
Difference
−7.0 h
95% CI −11.5 to −2.6
P = 0.002
GA vs non-GA
difference −7.0 h (95% CI −11.5 to −2.6); P = 0.002
Observational data: associations, not effects.
Further findings
Adequate tolerance
- GA associated with adequate tolerance (OR)
- OR 43.18, 95%CI [5.91; 5501.94], p < 0.001
- After inverse probability of treatment weighting (IPTW)
Need for a second endoscopy
- GA associated with reduced need for a second endoscopy (OR)
- OR 4.64, [1.38; 15.63], p = 0.013
- After IPTW
Safety
Post-endoscopy respiratory or cardiovascular complications; in-hospital mortality
- GA not associated with increased complications or in-hospital mortality
- After IPTW
Original publication
General anesthesia with intubation and emergency endoscopy outcomes in patients with upper gastrointestinal bleeding: an inverse probability of treatment weighting study. Anaesth Crit Care Pain Med. Published 22 March 2026. doi:10.
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