Generalizability of nociception level as a measure of intraoperative nociceptive stimulation: A retrospective analysis
Authors' conclusion
Nociception level appears to provide accurate estimates of intraoperative nociception over a broad range of patients and anesthetic conditions.
Study context
- Population
- Noncardiac surgical patients enrolled in prospective nociception level (NOL) validation studies447 of 522 patients analysed
- Participants
- 315 vs 361
- Exposure
- Noxious stimuli vs Non-noxious stimuli
- Noxious stimulin = 315
- Non-noxious stimulin = 361reference
- Outcome
- NOL response (nociception index 0–100) to noxious and non-noxious stimuli, and its similarity across patient and anaesthetic subgroups
Methodological detailspooled trial data from eight prospective NOL validation studies
- Pooled trial data from eight prospective NOL validation studies
Main finding
As reported in the abstract
NOL response to stimuli
| Group | Value | 95% CI |
|---|---|---|
| Noxious stimuli | average 47 (SD 15) | 45-49 |
| Non-noxious stimuli | average 10 (SD 12) | 9-11 |
Value
Noxious stimuliaverage 47 (SD 15)
Non-noxious stimuliaverage 10 (SD 12)
95% CI
Noxious stimuli45-49
Non-noxious stimuli9-11
Observational data: associations, not effects.
Original publication
Generalizability of nociception level as a measure of intraoperative nociceptive stimulation: A retrospective analysis. Acta Anaesthesiol Scand. Published 14 June 2023. doi:10.
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