Does Nociception Level Index-Guided Opioid Administration Reduce Intraoperative Opioid Consumption? A Systematic Review and Meta-Analysis
Pooled result · Low certainty of evidenceResult — go to the resultSMD −0.26 95% CI −0.82 to 0.30Authors' conclusion
This meta-analysis does not provide evidence supporting the role of NOL monitoring in reducing intraoperative opioid consumption.
Study context
- Population
- Adults undergoing any type of surgery
- Participants
- 519 adults · 9 trials
- Comparison
- Nociception level (NOL)-guided opioid administration vs conventional therapy
- Outcome
- Intraoperative opioid consumption (SMD; 0.20 small, 0.80 large effect)
Methodological detailsrandom-effects model with Hartung-Knapp-Sidik-Jonkman adjustment, Grading of Recommendations, Assessment, Development, and Evaluations (GRADE)
- Random-effects model with Hartung-Knapp-Sidik-Jonkman adjustment
- GRADE
Pooled result
Low certainty of evidence
SMD
−0.26
95% CI −0.82 to 0.30
P = 0.31
NOL monitoring vs Conventional therapy
SMD −0.26 (95% CI −0.82 to 0.30); P = 0.31
As reported in the abstract
Original publication
Does Nociception Level Index-Guided Opioid Administration Reduce Intraoperative Opioid Consumption? A Systematic Review and Meta-Analysis. Anesth Analg. Published 2 August 2024. doi:10.
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