ICU sedation, delirium & recovery
Genome-Wide DNA Methylation Profiles of Long-Term Cognitive Decline after Delirium in Intensive Care Unit Patients
Authors' conclusion
This genome-wide DNAm analysis focused on LTCD after delirium highlights differentiating epigenetic signals related to MHC class II and immune processes.
Study context
- Population
- Intensive care unit (ICU) patients with and without delirium
- Participants
- 104 patients
- Comparison
- Delirium patients with vs without long-term cognitive decline
- Deliriumn = 86
- Nondeliriumn = 18
- Outcome
- Differences in genome-wide DNA methylation associated with LTCD after delirium
Methodological detailsgenome-wide DNA methylation (Illumina EPIC array), gene ontology (GO) and KEGG enrichment analyses
- Genome-wide DNA methylation (Illumina EPIC array)
- GO and KEGG enrichment analyses
Main finding
As reported in the abstract
Differentially methylated CpG sites associated with LTCD in delirium patients
- Cytosine-phosphate-guanine (CpG) in major histocompatibility complex (MHC) region on chromosome 6 (cg11103845) significantly associated with long-term cognitive decline (LTCD) after false discovery rate (FDR) correction
- FDR-adjusted P = .034
Original publication
Genome-Wide DNA Methylation Profiles of Long-Term Cognitive Decline after Delirium in Intensive Care Unit Patients. Anesth Analg. Published 16 September 2025. doi:10.
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