Hemodynamics, fluids & transfusion
German Patient Blood Management Network: effectiveness and safety analysis in 1.2 million patients
Authors' conclusion
Analysis of >1 million surgical patients showed that the non-inferiority condition (safety of Patient Blood Management) was fulfilled, and PBM was superior with respect to red blood cell transfusion.
Study context
- Population
- In-hospital adults (≥18 yr) undergoing surgery and discharged between January 1, 2010 and December 31, 2019, in 14 German hospitals
- Participants
- 1,201,817 adults · 14 hospitals
- Comparison
- Patient Blood Management (PBM) vs pre-PBM
- PBMn = 760,735
- pre-PBMn = 441,082reference
- Outcome
- Composite of:
- In-hospital mortality
- Postoperative complications (MI/ischaemic stroke/acute renal failure with RRT/sepsis/pneumonia)
Methodological detailsnon-inferiority, data retrospectively extracted from hospital information systems
- Non-inferiority
- Data retrospectively extracted from hospital information systems
Main finding
As reported in the abstract
P < 0.001
Further findings
RBC units transfused per 1000 patients
- RBC units transfused per 1000 patients — Relative reduction with PBM
- 13.9%
RBC transfusion rate
- RBC transfusion rate significantly lower, OR
- 0.86 (0.85-0.87), P<0.001
Original publication
German Patient Blood Management Network: effectiveness and safety analysis in 1.2 million patients. Br J Anaesth. Published 26 June 2023. doi:10.
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