Glucagon-Like Peptide-1 Receptor Agonist Use and Residual Gastric Content Before Anesthesia
Authors' conclusion
Use of a GLP-1 RA was independently associated with increased RGC on preprocedural gastric ultrasonography.
Study context
- Population
- Patients following preprocedural fasting guidelines before an elective procedure under anesthesia at a large tertiary university-affiliated hospital, June–July 2023
- Participants
- 124 patients
- Exposure
- Once-weekly GLP-1 RA use vs no GLP-1 RA use
- Exposuren = 62
- Controln = 62reference
- Outcome
- Increased residual gastric content (solids, thick liquids, or >1.5 mL/kg clear liquids on gastric ultrasonography)
Methodological detailsprospective enrolment, single-centre, augmented inverse probability of treatment weighting (propensity score-based)
- Prospective enrolment
- Single-centre
- Augmented inverse probability of treatment weighting (propensity score-based)
Main finding
As reported in the abstract
Each group vs controlAdjusted prevalence ratio (95% CI)
Exposure
2.48(1.23–4.97)
Each group vs controlDifference in prevalence (95% CI)
Exposure
30.5%(9.9%–51.2%)
Observational data: associations, not effects.
Further findings
Duration of GLP-1 RA interruption and increased residual gastric content
| aOR (95% CI) | ||
|---|---|---|
| Duration of GLP-1 RA interruptionNo association | 0.86 (0.65–1.14) | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Glucagon-Like Peptide-1 Receptor Agonist Use and Residual Gastric Content Before Anesthesia. JAMA Surg. Published 1 June 2024. doi:10.
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