Granulocyte and monocyte adsorption therapy in sepsis: a propensity score-matched analysis
Authors' conclusion
In this multi-dataset analysis, patients treated with G1-DHP showed lower mortality and more favorable clinical outcomes in comparison to external controls.
Study context
- Population
- Patients with sepsis71, 72 and 68 matched pairs
- Exposure
- G1-DHP vs external controls
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailspropensity-score matched, one-to-one nearest-neighbor matching, multicentre, exploratory
- Propensity-score matched
- One-to-one nearest-neighbor matching
- Multicentre
- Exploratory
Main finding
As reported in the abstract
Mortality, % vs %
5.6% vs. 23%
P < 0.01
G-1 trial vs JSEPTIC-DIC
Mortality, % vs %
5.6% vs. 28%
P < 0.01
G-1 trial vs FORECAST
Mortality, % vs %
5.9% vs. 38%
P < 0.01
G-1 trial vs JMDC
Observational data: associations, not effects.
Secondary outcomes
Ventilator-free period
- Significantly longer in the G-1 trial
Intensive care unit (ICU)-free period
- Trend toward longer in the G-1 trial
Sequential Organ Failure Assessment (SOFA) score improvement · day 7
- Greater observed improvement with G1-DHP vs controls; liver and coagulation subscores particularly notable
Original publication
Granulocyte and monocyte adsorption therapy in sepsis: a propensity score-matched analysis. J Intensive Care. Published 16 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →