Cardiac arrest & resuscitation
Health-related quality of life and cognitive function after out-of-hospital cardiac arrest; a comparison of prehospital return-of-spontaneous circulation and refractory arrest managed with extracorporeal cardiopulmonary resuscitation
Authors' conclusion
Despite substantially longer low flow times with thrice as high lactate levels, ECPR-survivors were similar in cognitive and physical function compared to sACLS-survivors. Nonetheless, ECPR-survivors reported lower HRQoL overall and related to mental health, pain management, and the perception of limitations in physical role.
Study context
- Population
- Survivors of out-of-hospital cardiac arrest (OHCA)
- Participants
- 15 vs 22
- Exposure
- Extracorporeal cardiopulmonary resuscitation (ECPR)-survivors vs standard advanced cardiac life support (sACLS)-survivors
- ECPRn = 15
- sACLSn = 22reference
- Outcome
- HRQoL (EQ-5D-5L, SF-36) and cognitive function
Methodological detailsage-matched
- Age-matched
Main finding
As reported in the abstract
HRQoL
| Group | EQ-5D-5L index score | EQ-5D-5L visual analog scale |
|---|---|---|
| ECPR | 0.73 | 70 |
| sACLS | 0.86 | 84 |
EQ-5D-5L index score
ECPR0.73
sACLS0.86
EQ-5D-5L visual analog scale
ECPR70
sACLS84
- ECPR vs sACLS: P = 0.03 — EQ-5D-5L index score
- ECPR vs sACLS: P = 0.04 — visual analog scale
Observational data: associations, not effects.
Further findings
| Outcome | ECPR | sACLS |
|---|---|---|
| Low flow time and lactateSignificantly longer / higher in ECPR | ||
| Low flow time | 86 min | 15 min |
| Lactate | 14.1 mmol/l | 3.9 mmol/l |
Physical function
- No between-group difference
Original publication
Health-related quality of life and cognitive function after out-of-hospital cardiac arrest; a comparison of prehospital return-of-spontaneous circulation and refractory arrest managed with extracorporeal cardiopulmonary resuscitation. Resuscitation. Published 23 February 2024. doi:10.
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