Cardiac arrest & resuscitation
Serum lactate in refractory out-of-hospital cardiac arrest: Post-hoc analysis of the Prague out-of-hospital cardiac arrest (OHCA) study
Authors' conclusion
In refractory OHCA serum lactate concentrations measured anytime during the first 24 h after admission to the hospital were found to correlate with the outcome in patients treated by ECPR but not in patients with prehospital ROSC.
Study context
- Population
- Refractory OHCA
- Participants
- 92 vs 82
- Comparison
- Serum lactate in extracorporeal cardiopulmonary resuscitation (ECPR) vs prehospital ROSC
- ECPRn = 92
- ROSCn = 82
- Primary endpoint
- Neurological outcome (best Cerebral Performance Category score) predicted by lactate on admission and every 4 h during first 24 h
- Follow-up
- Within 180 days post-cardiac arrest
Methodological detailspost-hoc analysis
- Post-hoc analysis
Primary result
As reported in the abstract
Admission serum lactate predicting unfavorable neurological outcome · On admission
| Group | Cut-off | Specificity | Sensitivity | Favorable neurological outcome |
|---|---|---|---|---|
| ECPR | >14.0 mmol/L | 87.5% | 54.4% | 26% |
| ROSC | >10.8 mmol/L | 83% | 41.2% | 59% |
Cut-off
ECPR>14.0 mmol/L
ROSC>10.8 mmol/L
Specificity
ECPR87.5%
ROSC83%
Sensitivity
ECPR54.4%
ROSC41.2%
Favorable neurological outcome
ECPR26%
ROSC59%
Original publication
Serum lactate in refractory out-of-hospital cardiac arrest: Post-hoc analysis of the Prague OHCA study. Resuscitation. Published 11 August 2023. doi:10.
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