Cardiac arrest & resuscitation
Extracorporeal cardiopulmonary resuscitation-based approach to refractory out-of-hospital cardiac arrest: A focus on organ donation, a secondary analysis of a Prague out-of-hospital cardiac arrest (OHCA) randomized study
Authors' conclusion
The ECPR-based approach in the refractory OHCA trial is associated with increased organ donorship and an excellent outcome of transplanted organs.
Study context
- Population
- Adults with witnessed refractory OHCA of presumed cardiac origin
- Participants
- 256 adults
- Comparison
- Extracorporeal cardiopulmonary resuscitation (ECPR)-based vs standard approach
- Primary endpoint
- Organ donation rates and 1-year organ survival in recipients
Methodological detailspost-hoc analysis
- Post-hoc analysis
Primary result
As reported in the abstract
Considered organ donors
| Group | Value | Accepted donors |
|---|---|---|
| ECPR | 21 events | 13 |
| Standard | 3 events | two |
Value
ECPR21 events
Standard3 events
Accepted donors
ECPR13
Standardtwo
- ECPR vs Standard: P = 0.01 — considered donors 21 vs 3
- Total considered donors
- 24
- Accepted donors: brain-dead
- Fifteen
- Accepted donors: cardiac-dead
- none
Further findings
Mortality
- Died prehospitally or within 1 hour after admission
- 75 (29%)
- Died during hospital stay
- 107 (42%)
Organs harvested and transplanted · 1 year post-transplant
- Organs harvested
- 36
- Recipients transplanted
- 34
- All transplanted organs fully functional; recipient deaths due to graft failure
- none
Original publication
Extracorporeal cardiopulmonary resuscitation-based approach to refractory out-of-hospital cardiac arrest: A focus on organ donation, a secondary analysis of a Prague OHCA randomized study. Resuscitation. Published 6 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →